The comic will visit Stockton and Durham with his new Right Man, Wrong Age show in the coming months.
The club, which takes places at The Witham Arts Centre, Barnard Castle, will host three evenings of comedy, featuring seven of the country’s top comics, throughout the season.
Professional comics John Scott and Paul Sneddon will host the workshops, which run for six weeks beginning on Tuesday 19 Apr at 7pm.
The popular Irish troupe will bring their new show Skiddlywup to The Stand on Tuesday 12 April.
Byrne, who has previously appeared on Live at the Apollo, The Royal Variety Show, Dave’s One Night Stand and The John Bishop Show, will play Stockton’s ARC on Thursday 24 November.
Pete Firman’s new show TriX will see him bring his trademark blend of crowd-pleasing comedy and jaw-dropping magic to Teesdale, fresh from his 10th year at the Edinburgh Festival.
Potential entrants have until 29 May to submit their sketch ideas, with the best six being selected by comics Jason Cook and Gavin Webster.
Live stand-up comedy returns to Newcastle next month with a headline appearance from Patrick Monahan.